【大師講壇】第248期:單分子的力量:從閃爍的單分子到(生物)材料研究與應用
單分子光譜學在其應用的每一個領域都產生了巨大的影響,范圍從催化、等離激元學、聚合物物理、生物物理到細胞生物學和DNA測序。此外,單分子技術使研究人員能夠將熒光顯微鏡的分辨率推至衍射極限以下。在本次報告中,我將概述近年來(基于單分子的)顯微鏡模態的發展,這些發展與專用標記物和連接化學的合成密切相關。我將通過展示我實驗室中當前的主要研究方向,來說明這些顯微鏡技術的發展如何推動了生物/材料科學的研究。
Single molecule spectroscopy has tremendously impacted every field in which the technique was applied, ranging from catalysis over plasmonics, polymer physics, biophysics to cell biology and DNA sequencing. Furthermore, single molecule techniques have allowed researchers to push the resolution of fluorescence microscopy past the diffraction limit. In this presentation, I will give an overview of recent (single molecule based) microscopy modality developments that go hand in hand with the synthesis of dedicated labels and linker chemistry. I will show how these microscopy developments have been driving research in bio/material science, by exemplifying major current research lines in my laboratory.